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    Indivina 1 mg/5 mg tablets - Summary of Product Characteristics ...

    Indivina 1 mg/5 mg tablets - Summary of Product Characteristics ...
    If breakthrough bleeding occurs and persists, and endometrial abnormality has been ruled out, the dose can be increased to 5 mg (Indivina 1mg/5 mg tablet).

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    If you are going to have surgery, tell the surgeon that you are taking indivina. Patients with rare hereditary problems of galactose intolerance, the lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine. Estrogen overdose may cause nausea, headache and uterine bleeding.

    Some medicines may interfere with the effect of indivina. Indivina 1 mg5 mg tablets are white, round, bevelled-edge, diameter 7 mm, flat tablets with a code 1 5on one side. Women who switch from cyclic hrt regimen should start indivina treatment one week after completion of the cycle.

    Undesirable effects according to system organ class associated with hrt treatment are presented in the table below. Breast paintension, unscheduled vaginal bleeding or spotting, vaginal discharge, disorder of vulvavagina, menstrual disorder breast enlargement, breast tenderness, endometrial hyperplasia, uterine disorder have been reported in single cases in clinical trials. After 4 years of treatment with indivina combinations containing the 1 mg dose, the increase in lumbar spine bone mineral density (bmd) was 6.

    Its metabolites are excreted in the urine as glucuronide and sulfate conjugates together with a small proportion of unchanged estradiol. However, if this is still happening after a few months or if you experience heavy bleeding tell your doctor. S, or protein c deficiencies or a combination of defects) hrt is contraindicated.

    You should then continue by taking the next tablet at your usual time. Do not use this medicine after the expiry date which is stated on the pack. Data on limited number of exposed pregnancies indicate no adverse effects of medroxyprogesterone acetate on the foetus.

    Other adverse reactions have been reported in association with estrogenprogestagen treatment an up to 2-fold increased risk of having breast cancer diagnosed is reported in women taking combined oestrogen-progestagen therapy for more than 5 years. Hormone replacement therapy (hrt) for estrogen deficiency symptoms in women with an intact uterus more than three years after menopause prevention of osteoporosis in postmenopausal women at high risk of future fractures who are intolerant of, or contraindicated for, other medicinal products approved for the prevention of osteoporosis. This may include an examination of your breasts andor an internal examination, if necessary. Previous idiopathic or current venous thromboembolism deep venous thrombosis (dvt), pulmonary embolism - known thrombophilic disorders (e. By continuing to browse the site you are agreeing to our policy on the use of cookies.

    Indivina 1 mg/5 mg tablets - Patient Information Leaflet (PIL) - (eMC)

    Below is a text only representation of the Patient Information Leaflet. The original can be viewed in PDF format using the link above. The text only version may be ...

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    Indivina 1mg 5mg Cialis Sale Previous idiopathic or current venous thromboembolism deep venous thrombosis (dvt), pulmonary embolism - known thrombophilic disorders (e, Before initiating or reinstituting hrt. Evidence from the whi trial and meta-analysed trials shows that current use of hrt, alone or in combination with a progestagen given to predominantly healthy women reduces the risk of hip, vertebral, and other osteoporotic fractures. Women with a tendency to chloasma should minimise exposure to the sun or ultraviolet radiation whilst taking hrt. The relevance of these data for human exposure is unknown (see section 4. If you are not having periods and you have not previously taken hrt or you are changing from another continuous combined hrt product, treatment with indivina may be started on any day.
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    For women in their 50s who are taking hrt, there will be 11 cases in 1,000 users, over 5 years (i. Other binding proteins may be elevated in serum, i. Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. The risk of haemorrhagic stroke is not increased during use of hrt. Medroxyprogesterone acetate binds to progestin-specific receptors and acts on the endometrium to convert the status of the endometrium from proliferative to secretory.

    The percentage of women who gained bmd in hip zone during treatment was 72. Looking at women in their 50s who are not taking hrt, on average, 8 in 1,000 would be expected to have a stroke over a 5-year period. C, protein s, or antithrombin deficiency, see section 4. Indivina combinations containing the 1 mg dose also had an effect on hip bmd. If you have or have had cholasma (yellowish-brown pigmentation patches on the skin, particularly of the face) if so, minimize your exposure to the sun or ultraviolet radiation whilst using indivina.

    During the menopause, the amount of the oestrogen produced by a womans body drops. If pregnancy occurs during medication with indivina, treatment should be withdrawn immediately. Numerous reports on high doses of estrogen-containing oral contraceptives ingested by young children indicate that serious harmful effects do not occur. Swallow the tablet whole with a drink if necessary. Like all medicines, this medicine can cause side effects, particularly early on (in the first few months of treatment), for example irregular bleeding may occur. Hrt, especially estrogen-progestagen combined treatment, increases the density of mammographic images which may adversely affect the radiological detection of breast cancer. Due to the low level of absolute risk in younger women, however, the balance of benefits and risks for these women may be more favourable than in older women. Medroxyprogesterone showed embryotoxic effects and induced anti-androgenic effects in male foetuses and masculinization in female foetuses. Tablet should be taken approximately at the same time of the day. Estrogens increase thyroid binding globulin (tbg), leading to increased circulating total thyroid hormone, as measured by protein-bound iodine (pbi), t4 levels (by column or by radio-immunoassay) or t3 levels (by radio-immunoassay).

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