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    Pearson, valeants chief executive, looked distracted when he took the stage in mid-october at a party meant to energize the addyi sales team, a description the company denies. Valeant has acknowledged that sales of addyi have not lived up to expectations and that it plans to invest more in the drug. That is the average benefit a woman gets when she takes the new female libido drug, sometimes called the female , flibanserin, making it the first drug available to treat low sexual desire in women.

    In addition, sprout prepared pamphlets and other marketing materials and enlisted doctors as expert speakers for addyi. Addyi would have to carry a black box warning, the most serious kind, stating that taking the drug with alcohol can cause dangerous drops in blood pressure or fainting. .

    Schiller, who represents the sprout shareholders, said in a statement that valeant was not meeting the obligations it agreed to with sprout, to the detriment of sprout shareholders, valeants own shareholders, its debt holders and the millions of women who would benefit from addyi. In their letter to valeant, angry sprout shareholders asked the company to explain its actions. Ackman, the hedge fund manager and one of valeants biggest backers.

    The companys experience was in selling older products with a well-established market, not new drugs. On monday, valeant dismissed the entire sales force behind the drug and said it planned to reintroduce addyi this year. Insurance companies, she said, would most likely receive discounts to make the drug cost less than 800.

    Former sprout employees say that the changes in marketing strategy complicated their efforts to sell doctors on the pill. Sprout also added 12 regional managers and nearly 150 sales representatives. That didnt work, but some early clinical trials did show an increase in sex drive among women.

    Streicher, a chicago gynecologist who specializes in sexual health. His fund, pershing square capital management, became a top shareholder of valeant when its shares were flying high. Today, as addyi struggles, valeants broader difficulties could limit its ability to invest in the drugs marketing effort. Cindy whitehead, who was sprouts chief executive, left valeant pharmaceuticals when distribution of addyi lagged. Experts who had opposed the drugs approval said the jama analysis, which confirmed that the drug increased the risk of dizziness, sleepiness, nausea and fatigue, underscored the meagerness of the benefit.


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    Tage ramakrishna, the chief medical officer at valeant, the company that now owns the drug, said that the new analysis confirmed the findings of the clinical trials and provided little additional context. Cvscaremark, the pharmacy benefits manager, notified valeant several weeks before the pills introduction that it would not cover addyi at the 800 price, according to a letter sprout shareholders sent to valeant in march. Lauren streicher, an associate clinical professor of obstetrics and gynecology at the feinberg school of medicine at northwestern memorial hospital in chicago, said a number of her patients have taken the drug and reported significant increases in libido. Ackman suggested the company needed management changes, valeant said it would replace mr. Now sprout shareholders, in their letter to valeant, say that relying on philidor to distribute addyi was a crucial mistake.

    Insurers would have difficulty denying coverage, company executives reasoned, if their product was the same price as the mens pills. And viagra, which can lead to side effects like dizziness and nausea, does not carry a black-box warning. Sure enough, after the drug was approved, anthem, one of the nations largest insurers, said it would cover the drug at the 400 price. But valeant then announced it was severing ties with philidor, leaving the drug without a distributor. Valeant pharmaceuticals international, a drug company whose deal-making acumen had made it a stock-market darling, bought sprout for an astonishing 1 billion twice its value just two months earlier.

    Pearson, valeants chief executive, looked distracted when he took the stage in mid-october at a party meant to energize the addyi sales team, a description the company denies. Doctors had prescribed the drug fewer than 4,000 times as of february. Six former sprout employees said the money helped pay for two national sales directors, including one who had sold viagra when it went on sale in 1998. Valeant also halted a planned speakers program, in which doctors explained the drug to their colleagues. Schiller, who represents the sprout shareholders, said in a statement that valeant was not meeting the obligations it agreed to with sprout, to the detriment of sprout shareholders, valeants own shareholders, its debt holders and the millions of women who would benefit from addyi. She said the company was preparing a speakers program. Ackman, the hedge fund manager and one of valeants biggest backers. Streicher, the chicago gynecologist, said she had prescribed the drug to only about 10 patients, to mixed reviews. Insurance companies, she said, would most likely receive discounts to make the drug cost less than 800. But when valeant took over, it ended this arrangement, former employees said, handing over that crucial job to philidor, which was out of business.

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    Feb 29, 2016 ... 'Female Viagra' may have risks The benefits of flibanserin for women's libido are ' marginal' considering its side-effects. To read more ...
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